1995;252 Suppl 1:S33-9. (Tokyo) 2007;53(2):124-132. (Lond) 2010;34(4):659-669. Proc.Am Thorac.Soc. Applies to capsaicintopical: topical cream, topical lotion, topical patch extended release, topical solution 2004;67(1):115-117. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Anesth.Analg. View abstract. J.Natl.Cancer Inst. Assessment by nasal biopsy of long-term use of mometasone furoate aqueous nasal spray (Nasonex) in the treatment of perennial rhinitis. Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. 2012;24(8):1682-1694. View abstract. Possible involvement of sensory neuropeptides in the flare reaction. Paice JA, Ferrans CE, Lashley FR, et al. Int J Clin Pharmacol Ther 1997;35(7):296-301. Mou J, Paillard F, Turnbull B, et al. Drug information provided by: IBM Micromedex. Hendrix, C. R., Housh, T. J., Mielke, M., Zuniga, J. M., Camic, C. L., Johnson, G. O., Schmidt, R. J., and Housh, D. J. Br.J.Nutr. View abstract. Capsaicin aqueous nasal spray has previously been shown to reduce nasal complaints without affecting cellular homeostasis or overall neurogenic staining up to 9 months after treatment. View abstract. 2014;42(3):263-5. HHS Webster, L. R., Malan, T. P., Tuchman, M. M., Mollen, M. D., Tobias, J. K., and Vanhove, G. F. A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. Contact dermatitis associated with capsaicin: Hunan hand syndrome. View abstract. View abstract. Sharma A, Gautam S, Jadhav SS. 2011;93(2):187-197. Drug Metab Pharmacokinet. Food Chem Toxicol 1996;34:313-6. View abstract. Dig.Dis.Sci 2011;56(12):3546-3550. Am.J.Forensic Med.Pathol. Methods: 9-4-2002;94(17):1281-1292. Cruz L, Castañeda-Hernández G, Navarrete A. Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral asprin administration in the rat. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. It is also used for muscular pain, back pain, and pain after surgery. Pain 2003;106:59-64. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. 2004;3:Doc04. Herbert, M. K., Tafler, R., Schmidt, R. F., and Weis, K. H. Cyclooxygenase inhibitors acetylsalicylic acid and indomethacin do not affect capsaicin-induced neurogenic inflammation in human skin. Ziegler, D. Painful diabetic neuropathy: advantage of novel drugs over old drugs? View abstract. Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. J.Agric.Food Chem. Olajos, E. J. and Salem, H. Riot control agents: pharmacology, toxicology, biochemistry and chemistry. View abstract. Locock RA. Keitel W, Frerick H, Kuhn U, et al. View abstract. 2009;129(4):367-371. COVID-19 is an emerging, rapidly evolving situation. View abstract. Dermatol 1996;93:61-2. View abstract. Klimek L, Bardenhewer C, Spielhaupter M, Harai C, Becker K, Pfaar O. HNO. Eur J Pain 2011;15(6):561-567. Lotti, T., Teofoli, P., and Tsampau, D. Treatment of aquagenic pruritus with topical capsaicin cream. 2000;18(3):271-272. View abstract. View abstract. Calixto, J. Intranasal medications for the treatment of migraine and cluster headache. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Semin Arthr Rheum 1994;23:41-7. conoides and garlic Allium sativum on plasma lipid levels and cecal microflora in mice fed beef tallow. Using capsicum along with cocaine might increase the side effects of cocaine, including heart attack and death. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Wolff, R. F., Bala, M. M., Westwood, M., Kessels, A. G., and Kleijnen, J. The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models. 2007;26 Suppl 1:3-106. Inoue, N., Matsunaga, Y., Satoh, H., and Takahashi, M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Ginsberg, F. and Famaey, J. P. A double-blind study of topical massage with Rado-Salil ointment in mechanical low-back pain. Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. 2004. BMC.Neurol. Capsaicin desensitization of the nasal mucosa reduces symptoms upon allergen challenge in patients with allergic rhinitis. Mil.Med. Not enough is known about the safety of giving capsicum to children by mouth. View abstract. Capsicum is taken by mouth for various problems with digestion including upset stomach, intestinal gas, stomach pain, diarrhea, and cramps. Gevorgyan A, Segboer C, Gorissen R, van Drunen CM, Fokkens W. Cochrane Database Syst Rev. View abstract. View abstract. 2001;19(5):929-939. Food Chem Toxicol 2002;40:1091-7. Systematic review of topical capsaicin for the treatment of chronic pain. View abstract. 2007;27:1237-47. View abstract. Fusco BM, Marabini S, Maggi CA, et al. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others. View abstract. Simpson DM, Brown S, Tobias J; NGX-4010 C107 Study Group. Pain Med. Food Chem.Toxicol. View abstract. Kahl, U. García-Menaya JM, Cordobés -Durán C, Bobadilla-González P, et al. 2009;60 Suppl 1:43-55. Kobata, K., Tate, H., Iwasaki, Y., Tanaka, Y., Ohtsu, K., Yazawa, S., and Watanabe, T. Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Kushnir, N. M. The role of decongestants, cromolyn, guafenesin, saline washes, capsaicin, leukotriene antagonists, and other treatments on rhinitis. Capsicum pain plaster in chronic non-specific low back pain. Advertising revenue supports our not-for-profit mission. Title 21. A systematic review and meta-analysis of energy intake data. Pain Pract. Along with its needed effects, a medicine may cause some unwanted effects. View abstract. 2005;43(1):66-75. An immunocytochemical study. Baudoin T, Kalogjera L, Hat J. Capsaicin significantly reduces sinonasal polyps. View abstract. Capsicum might also decrease blood sugar. 6-24-2009;57(12):5407-5412. Br.J Nutr. Tanaka, Y., Hosokawa, M., Otsu, K., Watanabe, T., and Yazawa, S. Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in capsicum cultivars. Blanc, P., Liu, D., Juarez, C., and Boushey, H. A. Lundblad, L., Lundberg, J. M., Anggard, A., and Zetterstrom, O. Capsaicin pretreatment inhibits the flare component of the cutaneous allergic reaction in man. 12-1-2011;31(12):877-882. These side effects tend to decrease and go away after 5 or more days of repeated use. There isn't enough information to know if capsicum is effective for the other conditions people use it for, including: colic, cramps, toothache, blood clots, fever, nausea, high cholesterol, heart disease, muscle spasms, laryngitis, and many others. View abstract. Ann Emerg Med 1995;25:713-5. View abstract. Recenti Prog Med. View abstract. Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. O'Connell F, Thomas VE, Pride NB, Fuller RW. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. The active chemical in capsicum, capsaicin, is approved by the FDA as an over-the-counter medication. Sicuteri F, Fusco BM, Marabini S, et al. Stephens, D. P., Charkoudian, N., Benevento, J. M., Johnson, J. M., and Saumet, J. L. The influence of topical capsaicin on the local thermal control of skin blood flow in humans. Free Radic.Res 2004;38(4):405-412. View abstract. Damaged or broken skin: Don't use capsicum on damaged or broken skin. Kang JY, Yeoh KG, Chia HP, et al. Misra, M. N., Pullani, A. J., and Mohamed, Z. U. Some people put capsicum inside the nose to treat hay fever, migraine headache, cluster headache, and sinus infections (sinusitis). Rapid Commun.Mass Spectrom. Side effects were minimal and limited to a mild stinging sensation that lasted only for a short time. 2006;52(4):336-342. Anesthesiol.Clin 2012;30(1):91-100. Clinical effects of oleoresin capsicum (pepper spray) on the human cornea and conjunctiva. Acta Otolaryngol Suppl 1993;500:88-91. Br.J.Pharmacol. Tolan, I., Ragoobirsingh, D., and Morrison, E. Y. Capsaicin patch (Qutenza) for postherpetic neuralgia. But it is POSSIBLY UNSAFE for your baby if you take capsicum by mouth. 1993;45(7):618-21. Ther Drug Monit. View abstract. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Hiura, A., Lopez, Villalobos E., and Ishizuka, H. Age-dependent attenuation of the decrease of C fibers by capsaicin and its effects on responses to nociceptive stimuli. Campbell, C. M., Bounds, S. C., Simango, M. B., Witmer, K. R., Campbell, J. N., Edwards, R. R., Haythornthwaite, J. 2010;11(4):600-608. Capsaicin aqueous nasal spray has previously been shown to reduce nasal complaints without affecting cellular homeostasis or overall neurogenic staining up to 9 months after treatment. This content does not have an English version. Ciabatti, P. G. and D'Ascanio, L. Intranasal Capsicum spray in idiopathic rhinitis: a randomized prospective application regimen trial. Bleeding disorders: While conflicting results exist, capsicum might increase the risk of bleeding in people with bleeding disorders. View abstract. Crimi, N., Polosa, R., Maccarrone, C., Palermo, B., Palermo, F., and Mistretta, A. Br.Med.J. Acta Neurol.Scand. Marks DR, Rapoport A, Padla D, et al. Spice extracts as dose-modifying factors in radiation inactivation of bacteria. View abstract. 1-15-1997;146(2):223-227. Minshall E, Ghaffar O, Cameron L, O'Brien F, Quinn H, Rowe-Jones J, Davies RJ, Prior A, Lund VJ, Mackay IS, Nolop K, Lutsky B, Durham SR, Hamid Q. Otolaryngol Head Neck Surg. View abstract. View abstract. Anaesthesia 2004;59(7):647-651. Effects of capsaicin on the pharmacokinetics of antipyrine, theophylline and quinine in rats. Br.J.Nutr. Lakartidningen 5-16-2002;99(20):2302-2303. One form of capsicum is currently being studied as a drug for migraine, osteoarthritis, and other painful conditions. No significant differences between both groups were found in pan-neurogenic staining of nasal mucosa using neurofilament and synaptophysine. Controlled study with long-term follow-up. 2009;32(21):3652-3658. Ann.Pharmacother. 1999;141(1):87-93. Blom HM, Van Rijswijk JB, Garrelds IM, et al.